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BIOPRESERVATION MEDIA INDUSTRY

Biopreservation is the exclusive biological approach designated for the preservation of cells, tissues and organs ex-vivo for the purpose of storage, shipment and transportation. Biopreservation media is one of the most crucial entity in conferring effective biopreservation. 

Biopreservation is the exclusive biological approach designated for the preservation of cells, tissues and organs ex-vivo for the purpose of storage, shipment and transportation. Biopreservation media is one of the most crucial entity in conferring effective biopreservation. The biopreservation technique utilizes the reduction in temperature concordant in maintaining the state of suspended animation of the biological material, wherein the cell functioning can be reduced in a reversible manner. The nature and complexity of the type of biological material is also the deciding factor for choosing the type of preservation.[1], [2] In retrospect, biopreservation media is classified into biopreservation media for hypothermic preservation and biopreservation media for cryopreservation. Hypothermic preservation occurs at temperatures above the freezing point of the solution but below the normothermic range of the cells, tissues and organs. In contrary, cryopreservation freezes and stores the biological materials at subzero or ultralow temperature range, where the biochemical events and molecular reactions are arrested, and molecular motion is suppressed.


These fully formulated biopreservation media substantially lead to standardized and reproducible biopreservation results. In addition, it subsides the likelihood of any genetic and cellular modification of the preserved entities, thereby, augmenting its persistent use by the researchers and clinicians. The following figure presents the prominent areas within pharmaceutical / biotechnology / healthcare industry where biopreservation media can be employed.


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§ Cold Chain:

Biopreservation media for hypothermic biopreservation and cryopreservation are pertinent for the preparation, storage and transportation of the biological materials.[3]


§ Cellular Therapy:

Biopreservation is a key component for keeping the clinical quality characteristic and sustaining the cell quality in order to obtain cellular therapy products for clinical and commercial usage. Further, the parameters considered in the selection of biopreservation are based upon the level of functioning post-thaw and administration of the preserved product directly into the patient, obviating the need for any animal-derived component-based media. Moreover, biopreservation media are frequently employed in cellular immunotherapy pertaining to T-cell receptor, tumor infiltrating lymphocytes, chimeric antigen receptor T-cells, dendritic cell and other immunotherapies targeting hematologic malignancies, solid tumors, other disorders and diseases.[4], [5], [6]

 

§ Regenerative Medicine:

Biopreservation medium for hypothermic and cryogenic storage have been widely used to cure a variety of diseases by replacing or regenerating the function of injured, damaged, or diseased cells, tissues, or organs by establishing or restoring the cell function. It is worth highlighting that these media are often used in shipping, storage, clinical administration process and commercialization of the products in the field of regenerative medicine / stem cell therapy.[7], [8], [9]

 

§ Biobanking:

Biopreservation is the forefront in the banking of various kinds of cells and tissues to facilitate the fundamental scientific research, organ transplantation, and tissue-engineered structures for further therapeutic applications. The usage of optimal biopreservation media aimed at high post-thaw cell recovery supports the buildup of knowledge relevant to the purpose supported by research laboratories, industrial, non-profit and government led biobanks.[10], [11]


§ Drug Discovery:

Biopreservation media has been widely recognized for its application in drug discovery industry. The cryopreservation medium provides a desired environment to preserve cells, tissue slices, tissues grown from stem cells required in the pharmaceutical research.[12], [13], [14]


§ Personalized Medicine:

Personalized medicine or precision medicine is an emerging field with the potential to develop novel and efficacious custom-based clinical therapies wherein biopreservation holds a potential role.[15]


You may also be interested in the following titles:

 

1.     https://www.rootsanalysis.com/reports/proteome-profiling-services.html

2.     https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/biopreservation



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